Abstract
Jahchan and colleagues report the use of a biostatistical analysis to identify effective therapeutics for small cell lung cancer (SCLC). Their results reveal a new use for the tricyclic antidepressant imipramine in SCLC and shed light on the therapeutic potential of drug repositioning in cancer and other diseases.
©2013 AACR.
MeSH terms
- Animals
- Antidepressive Agents, Tricyclic / pharmacology*
- Antineoplastic Agents / pharmacology*
- Drug Repositioning*
- Humans
- Lung Neoplasms / drug therapy*
- Neuroendocrine Tumors / drug therapy*
- Receptors, G-Protein-Coupled / antagonists & inhibitors*
- Small Cell Lung Carcinoma / drug therapy*
- Small Cell Lung Carcinoma / metabolism*
Substances
- Antidepressive Agents, Tricyclic
- Antineoplastic Agents
- Receptors, G-Protein-Coupled