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The Lancet is an international, weekly general medical journal founded in 1823 by Thomas Wakley. Since its first issue, the journal has strived to make science widely available so that medicine can serve, and transform society, and positively impact the lives of people. The Lancet is committed to applying scientific knowledge to improve health and advance human progress. In our weekly issues, and Online First content, we publish some of the best science from the best scientists worldwide, providing an unparalleled global reach and impact on health.