Bats Are Natural Reservoirs of SARS-Like Coronaviruses
Abstract
Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.
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This work was jointly funded by a special grant for “Animal Reservoir of SARS-CoV,†State Key Program for Basic Research Grant 2005CB523004, and State High Technology Development Program grant no. 2005AA219070 from the Ministry of Science and Technology, People's Republic of China; the Sixth Framework Program “EPISARS†from the European Commission (no. 51163); the Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease (Project 1.007R); and an NIH/NSF “Ecology of Infectious Diseases†award (no. R01-TW05869) from the John E. Fogarty International Center and the V. Kann Rasmussen Foundation. For the full-length genome sequence of SL-CoV Rp3, see GenBank accession no. DQ71615. Additional GenBank accession numbers are given in the supporting material.
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Science
Volume 310 | Issue 5748
28 October 2005
28 October 2005
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American Association for the Advancement of Science.
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Received: 4 August 2005
Accepted: 20 September 2005
Published in print: 28 October 2005
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