Phylogeny of a Novel Family of Human Endogenous Retrovirus Sequences, HERV-W, in Humans and Other Primates
Publication: AIDS Research and Human Retroviruses
Volume 15, Issue Number 17
Abstract
A novel human endogenous retrovirus, HERV-W, has been characterized on the basis of multiple sclerosisassociated retrovirus (MSRV) probes. We have analyzed the phylogenetic distribution of HERV-W in humans and other primate species. As HERV-W presents a C/D chimeric nature and is largely composed of deleted elements, Southern blots were performed using gag, pol, env, and LTR probes. The relative complexities observed for gag, pol, env, and LTR regions were similar in humans, apes, and Old World monkeys, the minimal number of bands observed after Southern blot analysis being 25, 50, 10, and at least 100, respectively. The HERV-W family entered the genome of catarrhines more than 25 million years ago.
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AIDS Research and Human Retroviruses
Volume 15 • Issue Number 17 • November 1999
Pages: 1529 - 1533
PubMed: 10580403
History
Published online: 5 July 2004
Published in print: November 1999
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