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33 result(s) for 'author#Thomas Jaki' within BMC

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  1. Despite the broad spectrum of antirheumatic drugs, RA is still not well controlled in up to 30-50 % of patients. Inhibition of JAK kinases by means of the pan-JAK inhibitor tofacitinib has demonstrated to be e...

    Authors: Alba Llop-Guevara, Mónica Porras, Carla Cendón, Irene Di Ceglie, Francesco Siracusa, Federica Madarena, Vagelis Rinotas, Lluís Gómez, Peter L. van Lent, Eleni Douni, Hyun Dong Chang, Thomas Kamradt and Juan Román
    Citation: Arthritis Research & Therapy 2015 17:356
    Content type: Research article Published on:

  5. The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level.

    Authors: Iain B. McInnes, Nicole L. Byers, Richard E. Higgs, Jonathan Lee, William L. Macias, Songqing Na, Robert A. Ortmann, Guilherme Rocha, Terence P. Rooney, Thomas Wehrman, Xin Zhang, Steven H. Zuckerman and Peter C. Taylor
    Citation: Arthritis Research & Therapy 2019 21:183
    Content type: Research article Published on:

  6. Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host response and endothelial cell (EC) dysfunction. Ribonuclease 1 (RNase1) a...

    Authors: Katrin Laakmann, Jorina Mona Eckersberg, Moritz Hapke, Marie Wiegand, Jeff Bierwagen, Isabell Beinborn, Christian Preußer, Elke Pogge von Strandmann, Thomas Heimerl, Bernd Schmeck and Anna Lena Jung
    Citation: Cell Communication and Signaling 2023 21:111
    Content type: Research Published on:

  7. Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transp...

    Authors: Jeff Bierwagen, Marie Wiegand, Katrin Laakmann, Olga Danov, Hannah Limburg, Stefanie Muriel Herbel, Thomas Heimerl, Jens Dorna, Danny Jonigk, Christian Preußer, Wilhelm Bertrams, Armin Braun, Katherina Sewald, Leon N. Schulte, Stefan Bauer, Elke Pogge von Strandmann…
    Citation: Cell Communication and Signaling 2023 21:65
    Content type: Research Published on:

  8. Traditional, complementary, alternative and integrative medicine (TCAIM) can be described as diverse medical and healthcare interventions, practices, products, or disciplines that are not considered as part of...

    Authors: Jeremy Y. Ng
    Citation: BMC Complementary Medicine and Therapies 2021 21:185
    Content type: Research Published on:

  9. Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. ...

    Authors: Munyaradzi Dimairo, Philip Pallmann, James Wason, Susan Todd, Thomas Jaki, Steven A. Julious, Adrian P. Mander, Christopher J. Weir, Franz Koenig, Marc K. Walton, Jon P. Nicholl, Elizabeth Coates, Katie Biggs, Toshimitsu Hamasaki, Michael A. Proschan, John A. Scott…
    Citation: Trials 2020 21:528
    Content type: Methodology Published on:

  10. Early phase dose-finding (EPDF) trials are crucial for the development of a new intervention and influence whether it should be investigated in further trials. Guidance exists for clinical trial protocols and ...

    Authors: Olga Solovyeva, Munyaradzi Dimairo, Christopher J. Weir, Siew Wan Hee, Aude Espinasse, Moreno Ursino, Dhrusti Patel, Andrew Kightley, Sarah Hughes, Thomas Jaki, Adrian Mander, Thomas R. Jeffry Evans, Shing Lee, Sally Hopewell, Khadija Rerhou Rantell, An-Wen Chan…
    Citation: BMC Medicine 2023 21:246
    Content type: Research article Published on:

  11. Embryonic stem cells (ESCs) provide an attractive cell source for basic research and disease treatment. Currently, the common culture system for mouse ESC requires mouse embryonic fibroblast (MEF) as a feeder ...

    Authors: Yu Ma, Junjie Gu, Chunliang Li, Xiaoyuan Wei, Fan Tang, Guilai Shi, Jing Jiang, Ying Kuang, Jinsong Li, Zhugang Wang, Xin Xie and Ying Jin
    Citation: Stem Cell Research & Therapy 2012 3:29
    Content type: Research Published on:

  12. Phase I - To determine the optimal dose of each candidate (or combination of candidates) entered into the platform.

    Authors: Gareth Griffiths, Richard Fitzgerald, Thomas Jaki, Andrea Corkhill, Ellice Marwood, Helen Reynolds, Louise Stanton, Sean Ewings, Susannah Condie, Emma Wrixon, Andrea Norton, Mike Radford, Sara Yeats, Jane Robertson, Rachel Darby-Dowman, Lauren Walker…
    Citation: Trials 2020 21:544
    Content type: Letter Published on:

    The Update to this article has been published in Trials 2021 22:487

  13. The pathological mechanism in acute spinal cord injury (SCI) is dual sequential: the primary mechanical lesion and the secondary injury due to a cascade of biochemical and pathological changes initiated by the...

    Authors: Iris Leister, Rainer Mittermayr, Georg Mattiassich, Ludwig Aigner, Thomas Haider, Lukas Machegger, Harald Kindermann, Anja Grazer-Horacek, Johannes Holfeld and Wolfgang Schaden
    Citation: Trials 2022 23:245
    Content type: Study protocol Published on:

  14. Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations...

    Authors: James M. S. Wason, Munyaradzi Dimairo, Katie Biggs, Sarah Bowden, Julia Brown, Laura Flight, Jamie Hall, Thomas Jaki, Rachel Lowe, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Nina Wilson…
    Citation: BMC Medicine 2022 20:254
    Content type: Correspondence Published on:

  15. In the UK, the Medicines and Healthcare products Regulatory Agency consulted on proposals “to improve and strengthen the UK clinical trials legislation to help us make the UK the best place to research and dev...

    Authors: Martin Law, Dominique-Laurent Couturier, Babak Choodari-Oskooei, Phillip Crout, Carrol Gamble, Peter Jacko, Philip Pallmann, Mark Pilling, David S. Robertson, Michael Robling, Matthew R. Sydes, Sofía S. Villar, James Wason, Graham Wheeler, S. Faye Williamson, Christina Yap…
    Citation: Trials 2023 24:640
    Content type: Commentary Published on:

    The Correction to this article has been published in Trials 2023 24:744

  16. Adaptive designs for clinical trials permit alterations to a study in response to accumulating data in order to make trials more flexible, ethical, and efficient. These benefits are achieved while preserving t...

    Authors: Thomas Burnett, Pavel Mozgunov, Philip Pallmann, Sofia S. Villar, Graham M. Wheeler and Thomas Jaki
    Citation: BMC Medicine 2020 18:352
    Content type: Correspondence Published on:

  17. The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a global health emergency (COVID-19) because of its rapid spread and high mortality. Since the virus epidemic, ...

    Authors: Wenjing Gu, Hui Gan, Yu Ma, Lina Xu, Zhangkai J. Cheng, Bizhou Li, Xinxing Zhang, Wujun Jiang, Jinlv Sun, Baoqing Sun and Chuangli Hao
    Citation: Virology Journal 2022 19:49
    Content type: Review Published on:

  18. Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing ...

    Authors: Sean Ewings, Geoff Saunders, Thomas Jaki and Pavel Mozgunov
    Citation: BMC Medical Research Methodology 2022 22:25
    Content type: Research Published on:

  19. Despite optimal therapy, many children with Crohn’s disease (CD) experience growth retardation.

    Authors: Mabrouka A. Altowati, Ashley P. Jones, Helen Hickey, Paula R. Williamson, Farah M. Barakat, Nicolene C. Plaatjies, Ben Hardwick, Richard K. Russell, Thomas Jaki, S. Faisal Ahmed and Ian R. Sanderson
    Citation: Pilot and Feasibility Studies 2016 2:71
    Content type: Research Published on:

  20. Authors: Martin Law, Dominique-Laurent Couturier, Babak Choodari-Oskooei, Phillip Crout, Carrol Gamble, Peter Jacko, Philip Pallmann, Mark Pilling, David S. Robertson, Michael Robling, Matthew R. Sydes, Sofía S. Villar, James Wason, Graham Wheeler, S. Faye Williamson, Christina Yap…
    Citation: Trials 2023 24:744
    Content type: Correction Published on:

    The original article was published in Trials 2023 24:640