Coronavirus (Covid-19)
A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.
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In fully vaccinated patients with risk factors for severe disease and patients (vaccinated or unvaccinated) without such risk factors, nirmatrelvir–ritonavir did not significantly shorten the time to alleviation of Covid-19 symptoms.
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A 36-year-old man was evaluated in the infectious diseases clinic of the hospital because of fevers and throat discomfort that had begun 18 days earlier. An extensive workup was unrevealing. What is the diagnosis?
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Investigators found that persons with resolved persistent symptoms after Covid-19 had objectively measured cognition similar to that in persons with short-duration symptoms, although small deficits remained.
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Among Norwegian persons who had prospectively filled out questionnaires evaluating memory, problems with memory were more prominent after positive SARS-CoV-2 tests than after negative tests.
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Among more than 11,000 participants, 1.7% had at least one false positive rapid antigen test on the basis of RT-PCR results. Persistent false positives tended to occur in women and in persons with autoimmune abnormalities.
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Simnotrelvir has in vitro activity against SARS-CoV-2. In this phase 2–3 trial in China, simnotrelvir given within 72 hours after symptom onset led to symptom resolution approximately 36 hours faster than placebo.
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In this trial of simvastatin involving critically ill patients with Covid-19, which was stopped owing to reduced cases, simvastatin did not meet the prespecified criteria for superiority to control treatment.
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A 70-year-old woman with advanced HIV infection was evaluated because of cough, shortness of breath, and malaise. Eleven months earlier, she had received a diagnosis of Covid-19. A diagnosis was made.
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This report describes an increase in diagnoses of situs inversus on fetal ultrasonography beginning 4 months after the start of the SARS-CoV-2 surge in China in December 2022.
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A study suggests that prepandemic and SARS-CoV-2–negative cases that are indistinguishable from MIS-C are characterized by Vβ21.3+ T-cell expansion and may be triggered by other pathogens.
NEJM Covid-19 Update
HealthMap of the Coronavirus Outbreak
